Gene Expression Literature Summary

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Bmp4  bone morphogenetic protein 4   (Synonyms: Bmp2b, Bmp2b1, Bmp2b-1, Bmp-4)
Results	Reference
1	J:187154 Arora R, Metzger RJ, Papaioannou VE, Multiple roles and interactions of tbx4 and tbx5 in development of the respiratory system. PLoS Genet. 2012 Aug;8(8):e1002866
1	J:70592 Arteaga-Solis E, Gayraud B, Lee SY, Shum L, Sakai L, Ramirez F, Regulation of limb patterning by extracellular microfibrils. J Cell Biol. 2001 Jul 23;154(2):275-81
1	J:153595 Butterfield NC, Metzis V, McGlinn E, Bruce SJ, Wainwright BJ, Wicking C, Patched 1 is a crucial determinant of asymmetry and digit number in the vertebrate limb. Development. 2009 Oct;136(20):3515-24
1	J:226411 Caprioli A, Villasenor A, Wylie LA, Braitsch C, Marty-Santos L, Barry D, Karner CM, Fu S, Meadows SM, Carroll TJ, Cleaver O, Wnt4 is essential to normal mammalian lung development. Dev Biol. 2015 Oct 15;406(2):222-34
1*	J:267540 Cesario JM, Landin Malt A, Chung JU, Khairallah MP, Dasgupta K, Asam K, Deacon LJ, Choi V, Almaidhan AA, Darwiche NA, Kim J, Johnson RL, Jeong J, Anti-osteogenic function of a LIM-homeodomain transcription factor LMX1B is essential to early patterning of the calvaria. Dev Biol. 2018 Nov 15;443(2):103-116
1	J:121913 Cho SW, Lee HA, Cai J, Lee MJ, Kim JY, Ohshima H, Jung HS, The primary enamel knot determines the position of the first buccal cusp in developing mice molars. Differentiation. 2007 May 22;75(5):441-451
1*	J:42445 Dunn NR, Winnier GE, Hargett LK, Schrick JJ, Fogo AB, Hogan BL, Haploinsufficient phenotypes in Bmp4 heterozygous null mice and modification by mutations in Gli3 and Alx4. Dev Biol. 1997 Aug 15;188(2):235-47
1*	J:54066 Dupe V, Ghyselinck NB, Thomazy V, Nagy L, Davies PJA, Chambon P, Mark M, Essential roles of retinoic acid signaling in interdigital apoptosis and control of BMP-7 expression in mouse autopods. Dev Biol. 1999 Apr 1;208(1):30-43
1	J:183770 Funato N, Nakamura M, Richardson JA, Srivastava D, Yanagisawa H, Tbx1 regulates oral epithelial adhesion and palatal development. Hum Mol Genet. 2012 Jun 1;21(11):2524-37
1*	J:241980 Guo C, Sun Y, Guo C, MacDonald BT, Borer JG, Li X, Dkk1 in the peri-cloaca mesenchyme regulates formation of anorectal and genitourinary tracts. Dev Biol. 2014 Jan 01;385(1):41-51
1*	J:72303 Haraguchi R, Mo R, Hui C, Motoyama J, Makino S, Shiroishi T, Gaffield W, Yamada G, Unique functions of Sonic hedgehog signaling during external genitalia development. Development. 2001 Nov;128(21):4241-50
1	J:276702 Hildebrand L, Schmidt-von Kegler M, Walther M, Seemann P, Stange K, Limb specific Acvr1-knockout during embryogenesis in mice exhibits great toe malformation as seen in Fibrodysplasia Ossificans Progressiva (FOP). Dev Dyn. 2019 May;248(5):396-403
1	J:46930 Jiang R, Lan Y, Chapman HD, Shawber C, Norton CR, Serreze DV, Weinmaster G, Gridley T, Defects in limb, craniofacial, and thymic development in Jagged2 mutant mice. Genes Dev. 1998 Apr 1;12(7):1046-57
1*	J:54206 Jung HS, Oropeza V, Thesleff I, Shh, Bmp-2, Bmp-4 and Fgf-8 are associated with initiation and patterning of mouse tongue papillae. Mech Dev. 1999 Mar;81(1-2):179-82
1	J:231462 Kaltcheva MM, Anderson MJ, Harfe BD, Lewandoski M, BMPs are direct triggers of interdigital programmed cell death. Dev Biol. 2016 Mar 15;411(2):266-76
1	J:198828 Kelly CE, Thymiakou E, Dixon JE, Tanaka S, Godwin J, Episkopou V, Rnf165/Ark2C enhances BMP-Smad signaling to mediate motor axon extension. PLoS Biol. 2013;11(4):e1001538
1	J:86231 Kim JY, Mochizuki T, Akita K, Jung HS, Morphological evidence of the importance of epithelial tissue during mouse tongue development. Exp Cell Res. 2003 Nov 1;290(2):217-26
1	J:98917 Lallemand Y, Nicola MA, Ramos C, Bach A, Cloment CS, Robert B, Analysis of Msx1; Msx2 double mutants reveals multiple roles for Msx genes in limb development. Development. 2005 Jul;132(13):3003-14
1	J:314651 Lee JM, Miyazawa S, Shin JO, Kwon HJ, Kang DW, Choi BJ, Lee JH, Kondo S, Cho SW, Jung HS, Shh signaling is essential for rugae morphogenesis in mice. Histochem Cell Biol. 2011 Dec;136(6):663-75
1	J:104286 Levi G, Mantero S, Barbieri O, Cantatore D, Paleari L, Beverdam A, Genova F, Robert B, Merlo GR, Msx1 and Dlx5 act independently in development of craniofacial skeleton, but converge on the regulation of Bmp signaling in palate formation. Mech Dev. 2006 Jan;123(1):3-16
1	J:130228 Liu F, Chu EY, Watt B, Zhang Y, Gallant NM, Andl T, Yang SH, Lu MM, Piccolo S, Schmidt-Ullrich R, Taketo MM, Morrisey EE, Atit R, Dlugosz AA, Millar SE, Wnt/beta-catenin signaling directs multiple stages of tooth morphogenesis. Dev Biol. 2008 Jan 1;313(1):210-24
1*	J:146434 Maatouk DM, Choi KS, Bouldin CM, Harfe BD, In the limb AER Bmp2 and Bmp4 are required for dorsal-ventral patterning and interdigital cell death but not limb outgrowth. Dev Biol. 2009 Mar 15;327(2):516-23
1	J:155754 McCulloch DR, Nelson CM, Dixon LJ, Silver DL, Wylie JD, Lindner V, Sasaki T, Cooley MA, Argraves WS, Apte SS, ADAMTS metalloproteases generate active versican fragments that regulate interdigital web regression. Dev Cell. 2009 Nov;17(5):687-98
1	J:85946 Mucenski ML, Wert SE, Nation JM, Loudy DE, Huelsken J, Birchmeier W, Morrisey EE, Whitsett JA, beta-Catenin is required for specification of proximal/distal cell fate during lung morphogenesis. J Biol Chem. 2003 Oct 10;278(41):40231-8
1	J:262487 Murgai A, Altmeyer S, Wiegand S, Tylzanowski P, Stricker S, Cooperation of BMP and IHH signaling in interdigital cell fate determination. PLoS One. 2018;13(5):e0197535
1*	J:313342 Nichols DH, Bouma JE, Kopecky BJ, Jahan I, Beisel KW, He DZZ, Liu H, Fritzsch B, Interaction with ectopic cochlear crista sensory epithelium disrupts basal cochlear sensory epithelium development in Lmx1a mutant mice. Cell Tissue Res. 2020 Jun;380(3):435-448
1*	J:341657 Park J, Nakatomi M, Sasaguri M, Habu M, Takahashi O, Yoshiga D, Matsuyama K, Kataoka S, Toyono T, Seta Y, Peters H, Tominaga K, Msx1 Heterozygosity in Mice Enhances Susceptibility to Phenytoin-Induced Hypoxic Stress Causing Cleft Palate. Cleft Palate Craniofac J. 2021 Jun;58(6):697-706
1*	J:77812 Perriton CL, Powles N, Chiang C, Maconochie MK, Cohn MJ, Sonic hedgehog signaling from the urethral epithelium controls external genital development. Dev Biol. 2002 Jul 1;247(1):26-46
1*	J:35807 Phippard DJ, Weber-Hall SJ, Sharpe PT, Naylor MS, Jayatalake H, Maas R, Woo I, Roberts-Clark D, Francis-West PH, Liu YH, Maxson R, Hill RE, Dale TC, Regulation of Msx-1, Msx-2, Bmp-2 and Bmp-4 during foetal and postnatal mammary gland development. Development. 1996 Sep;122(9):2729-37
1	J:163666 Prochazka J, Pantalacci S, Churava S, Rothova M, Lambert A, Lesot H, Klein O, Peterka M, Laudet V, Peterkova R, Patterning by heritage in mouse molar row development. Proc Natl Acad Sci U S A. 2010 Aug 31;107(35):15497-502
1	J:167739 Sala FG, Del Moral PM, Tiozzo C, Alam DA, Warburton D, Grikscheit T, Veltmaat JM, Bellusci S, FGF10 controls the patterning of the tracheal cartilage rings via Shh. Development. 2011 Jan;138(2):273-82
1	J:94932 Satoh Y, Haraguchi R, Wright TJ, Mansour SL, Partanen J, Hajihosseini MK, Eswarakumar VP, Lonai P, Yamada G, Regulation of external genitalia development by concerted actions of FGF ligands and FGF receptors. Anat Embryol (Berl). 2004 Sep;208(6):479-86
1*	J:157085 Villacorte M, Suzuki K, Hayashi K, de Sousa Lopes SC, Haraguchi R, Taketo MM, Nakagata N, Yamada G, Antagonistic crosstalk of Wnt/beta-catenin/Bmp signaling within the Apical Ectodermal Ridge (AER) regulates interdigit formation. Biochem Biophys Res Commun. 2010 Jan 22;391(4):1653-7
1	J:272593 Volckaert T, Yuan T, Yuan J, Boateng E, Hopkins S, Zhang JS, Thannickal VJ, Fassler R, De Langhe SP, Hippo signaling promotes lung epithelial lineage commitment by curbing Fgf10 and beta-catenin signaling. Development. 2019 Jan 16;146(2):dev166454
1	J:154916 Welsh IC, O'Brien TP, Signaling integration in the rugae growth zone directs sequential SHH signaling center formation during the rostral outgrowth of the palate. Dev Biol. 2009 Dec 1;336(1):53-67
1	J:232140 Xu J, Liu H, Lan Y, Aronow BJ, Kalinichenko VV, Jiang R, A Shh-Foxf-Fgf18-Shh Molecular Circuit Regulating Palate Development. PLoS Genet. 2016 Jan;12(1):e1005769
1*	J:223183 Yang T, Jia Z, Bryant-Pike W, Chandrasekhar A, Murray JC, Fritzsch B, Bassuk AG, Analysis of PRICKLE1 in human cleft palate and mouse development demonstrates rare and common variants involved in human malformations. Mol Genet Genomic Med. 2014 Mar;2(2):138-51
1	J:90398 Zakin L, De Robertis EM, Inactivation of mouse Twisted gastrulation reveals its role in promoting Bmp4 activity during forebrain development. Development. 2004 Jan;131(2):413-24
1	J:104353 Zhang X, Stappenbeck TS, White AC, Lavine KJ, Gordon JI, Ornitz DM, Reciprocal epithelial-mesenchymal FGF signaling is required for cecal development. Development. 2006 Jan;133(1):173-80
1*	J:60837 Zhang Y, Zhang Z, Zhao X, Yu X, Hu Y, Geronimo B, Fromm SH, Chen YP, A new function of BMP4: dual role for BMP4 in regulation of Sonic hedgehog expression in the mouse tooth germ. Development. 2000 Apr;127(7):1431-43
1	J:156950 Zhao X, Brade T, Cunningham TJ, Duester G, Retinoic acid controls expression of tissue remodeling genes Hmgn1 and Fgf18 at the digit-interdigit junction. Dev Dyn. 2010 Feb;239(2):665-71
1	J:205040 Zhou J, Gao Y, Lan Y, Jia S, Jiang R, Pax9 regulates a molecular network involving Bmp4, Fgf10, Shh signaling and the Osr2 transcription factor to control palate morphogenesis. Development. 2013 Dec;140(23):4709-18